Publications by authors named "A Leader"
Background: Postpartum hemorrhage is considered a risk factor for pregnancy-associated complement-mediated hemolytic uremic syndrome (CM-HUS; previously known as atypical hemolytic uremic syndrome) but has not been systematically studied.
Objectives: To systematically examine the role of postpartum hemorrhage in precipitating CM-HUS and to describe the characteristics of postpartum hemorrhage-associated CM-HUS, its prognosis and recommended management.
Methods: A systematic review of individual participant data from case series and reports in addition to a case series from our institution.
Article Synopsis
- Managing cancer-associated thrombosis (CAT) poses challenges due to factors like bleeding risk, patient frailty, and drug interactions, necessitating careful treatment decisions.
- With the introduction of direct oral anticoagulants (DOACs), not all CAT patients benefit equally due to varied clinical and laboratory characteristics.
- This review discusses four specific scenarios in CAT management—brain metastasis, gastrointestinal malignancies, drug interactions, and thrombocytopenia—suggesting tailored treatment approaches based on current literature.
Management of anticoagulation in patients with brain metastasis.
Hematology Am Soc Hematol Educ Program
December 2024
Venous thromboembolism (VTE) is a prevalent and serious complication among cancer patients, necessitating therapeutic anticoagulation for many individuals with brain metastases. Simultaneously, patients with brain metastases, particularly those with high-risk primary tumors, have an increased risk of intracranial hemorrhage (ICH). Managing anticoagulation in these patients presents a dual challenge: preventing thromboembolism while avoiding hemorrhagic events.
View Article and Find Full Text PDFObjective: To improve mechanistic understanding, this randomized controlled trial examined anxiety, mood, emotional support, and pain-related self-efficacy as mediators of music therapy for pain management in people with advanced cancer.
Methods: People with advanced cancer who had chronic pain were randomized (1:1) to 6 weekly individual music therapy or social attention control sessions. We measured mediators and pain outcomes (pain interference and pain intensity) using self-report measures at baseline, session 4, and post-intervention.
Background: Despite the importance of community involvement in research, little formal training in community outreach and engagement (COE) is offered to cancer research trainees. A collaboration between the Office of COE and the Office of Cancer Research Training and Education Coordination (CRTEC) at the Sidney Kimmel Comprehensive Cancer Center at Jefferson led to the COE-CRTEC Trainee Working Group, a unique program in which trainees in cancer research each created a novel COE initiative.
Methods: Four cancer research trainees were selected to serve as COE Program Liaisons (CPLs), each aligned with one of the four cancer center research programs.