Publications by authors named "A Le Tellier"
There is uncertainty regarding which brand-name prescription drugs will have their prices negotiated by Medicare in 2025. This Viewpoint analyzes the process that will be used to select the next 15 drugs for price negotiation.
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- Understanding pathogen resistance genes, especially NLRs, in Solanum chilense requires looking at factors that influence gene gain and loss, which is detailed in a new reference genome study.
- The study reveals that variations in NLR loci across 20 populations show higher within-population diversity than between-population diversity, linking NLR diversity to population dynamics rather than environmental factors.
- Findings indicate that genetic drift and demographic history, along with some weak selection for local adaptation, significantly influence the evolution of NLRs in this plant species.
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- Drought stress significantly hinders plant growth, and this study focuses on how the wild tomato Solanum chilense adaptively responds to it in arid environments in South America.
- Through transcriptome analysis under varying conditions, researchers identify two main gene networks involved in drought response: one regulating the cell cycle, which is older and more stable, and another related to metabolism, which is newer and more variable.
- The integration of population genomics shows that older genes under positive selection are more interconnected in these networks, suggesting that adaptations to drought stress first occur in key genes, leading to changes that may contribute to species evolution and colonization of drier areas.
With the availability of high-quality full genome polymorphism (SNPs) data, it becomes feasible to study the past demographic and selective history of populations in exquisite detail. However, such inferences still suffer from a lack of statistical resolution for recent, for example bottlenecks, events, and/or for populations with small nucleotide diversity. Additional heritable (epi)genetic markers, such as indels, transposable elements, microsatellites, or cytosine methylation, may provide further, yet untapped, information on the recent past population history.
View Article and Find Full Text PDFHost-pathogen coevolution is defined as the reciprocal evolutionary changes in both species due to genotype × genotype (G×G) interactions at the genetic level determining the outcome and severity of infection. While co-analyses of hosts and pathogen genomes (co-genome-wide association studies) allow us to pinpoint the interacting genes, these do not reveal which host genotype(s) is/are resistant to which pathogen genotype(s). The knowledge of this so-called infection matrix is important for agriculture and medicine.
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