Publications by authors named "A Le Rhun"
Background: Effective emotional regulation is recognized as essential to a good mental health of people with chronic diseases, and Mind-body and Art Therapies (MBATs) could have a positive effect on emotional regulation skills in this population. Thus, we aimed to evaluate the effect of MBATs on emotional regulation as measured by the Difficulties in Emotion Regulation Scale (DERS) questionnaire.
Methods: A convergent mixed approach nested in a pragmatic superiority two arms parallel randomized controlled trial was conducted.
Methodologies for bacterial ribonuclease characterization using RNA-seq.
FEMS Microbiol Rev
September 2023
Bacteria adjust gene expression at the post-transcriptional level through an intricate network of small regulatory RNAs and RNA-binding proteins, including ribonucleases (RNases). RNases play an essential role in RNA metabolism, regulating RNA stability, decay, and activation. These enzymes exhibit species-specific effects on gene expression, bacterial physiology, and different strategies of target recognition.
View Article and Find Full Text PDFType I toxin-antitoxin systems (T1TAs) are extremely potent bacterial killing systems difficult to characterize using classical approaches. To assess the killing capability of type I toxins and to identify mutations suppressing the toxin expression or activity, we previously developed the FASTBAC-Seq (Functional AnalysiS of Toxin-Antitoxin Systems in BACteria by Deep Sequencing) method in Helicobacter pylori. This method combines a life and death selection with deep sequencing.
View Article and Find Full Text PDFBackground: How health-care professionals inform cystic fibrosis patients and their relatives about transplantation is not well known. Such information may not be provided in a timely or satisfactory manner. We conducted a survey about patient information practices among professionals from all French cystic fibrosis centers and transplant centers, to determine how they might be improved.
View Article and Find Full Text PDFArticle Synopsis
- RNA degradation is crucial for bacteria to manage gene expression and adapt to different environments, mainly through the actions of endoribonucleases (endoRNases) and exoribonucleases (exoRNases).
- The study specifically analyzes endoRNase Y and its interaction with three exoRNases in Streptococcus pyogenes, revealing that RNase Y primarily cuts after guanosine to create substrates for the exoRNases.
- The findings highlight the selective trimming of RNA fragments by PNPase and YhaM after RNase Y processing, demonstrating a novel approach to studying the complex interactions between RNA processing enzymes across the genome.