Publications by authors named "A Le Quellec"
Background And Aims: Systemic sclerosis (SSc) is an autoimmune connective disease characterised by excessive extracellular matrix deposition and widespread skin and internal organ fibrosis including various cardiac manifestations. Heart involvement is one of the leading causes of death among patients with SSc. In this study, we aimed to assess the effect of various vasodilator treatments.
View Article and Find Full Text PDFHeart and systemic sclerosis-findings from a national cohort study.
Rheumatology (Oxford)
November 2023
Objectives: Heart involvement is one of the leading causes of death in systemic sclerosis (SSc). The prevalence of SSc-related cardiac involvement is poorly known. Our objective was to investigate the prevalence and prognosis burden of different heart diseases in a nationwide cohort of patients with SSc.
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- - The study focused on examining the relationship between primary Sjögren's syndrome (pSS) and cancer, specifically analyzing the clinical, pathological, and immunological aspects of pSS patients who also had cancer, compared to those without cancer.
- - Out of 165 pSS patients, 55 had cancers, primarily solid neoplasms, with breast and lung cancers being the most common; significantly, many cancers were diagnosed close to or shortly after the pSS diagnosis.
- - Findings suggest that there may be a connection between breast cancers and pSS, implying that the immune system's behavior in pSS patients could play a role in cancer development or control.
Article Synopsis
- - The study evaluated malnutrition prevalence in systemic sclerosis (SSc) patients at a referral center from 1985 to 2019, finding that 59.2% were malnourished and 25% had severe malnutrition.
- - Malnutrition correlated with disease features, specifically cardiac involvement and limited mouth opening (interincisal distance <35 mm), indicating potential warning signs.
- - The findings suggest that addressing malnutrition could be crucial for improving health outcomes in SSc patients, given its high prevalence and associations with serious disease symptoms.
Objectives: This study aimed to estimate the prevalence of ANCA-associated vasculitis (AAV). That is, granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA) and eosinophilic granulomatosis with polyangiitis (EGPA), in Southern France in 2018, and evaluate differences among Europeans and non-Europeans.
Methods: This population-based, cross-sectional study used four sources (hospitals, community-based physicians, laboratories, National Health Insurance) to identify adults ≥15 years diagnosed with GPA, MPA or EGPA, living in Hérault and Gard in 2018.