Publications by authors named "A Le Guern"
Objective: New therapeutic classes of chemotherapy, including tyrosine kinase inhibitors (TKIs), are being developed, leading to unexpected cutaneous side-effects. The aim was to analyse the development of leg ulcers (LUs) associated with chemotherapy to identify their characteristics and management.
Method: A retrospective multicentre study was conducted across nine French dermatology departments and one haematology department.
Article Synopsis
- Enteric yersiniosis is a common food-borne illness in Europe, primarily monitored in France by the Yersinia National Reference Laboratory, which has been using whole genome sequencing (WGS) since 2017 to analyze isolates.
- From 2017 to 2021, a total of 7,642 strains were characterized, revealing the majority (87.2%) were from the most common pathogenic lineage (lineage 4).
- A new typing method called core genome Multilocus Sequence Typing (cgMLST) was developed to enhance surveillance, resulting in the identification of 419 clusters of pathogenic isolates, which aids in understanding outbreaks and cases more effectively.
Background: Studies demonstrating the potential utility of reflectance confocal microscopy (RCM) have been performed under experimental conditions.
Objective: To provide an overview of RCM practice in real-life.
Methods: A multicenter, prospective study carried out in 10 university dermatology departments in France.
Cathepsin D (CD) is overexpressed in several types of cancer and constitutes an important biological target. Pepstatin A, a pentapeptide incorporating two non-proteinogenic statin residues, is among the most potent inhibitor of CD but lacks selectivity and suffers from poor bioavailability. Eight analogues of Pepstatin A, were synthesized, replacing residues in P3 or P1 position by non-canonical (S)- and (R)-α-Trifluoromethyl Alanine (TfmAla), (S)- and (R)-Trifluoromethionine (TFM) or non-natural d-Valine.
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