Publications by authors named "A Layton"

Preeclampsia is a multisystem hypertensive disorder that manifests itself after 20 weeks of pregnancy, along with proteinuria. The pathophysiology of preeclampsia is incompletely understood. Artificial intelligence, especially machine learning with its capability to identify patterns in complex data, has the potential to revolutionize preeclampsia research.

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Acne and sensitive skin can take a profound toll on patients' well-being, which can be exacerbated if the conditions are experienced together. This narrative review aims to identify appropriate treatments to facilitate a holistic management approach to acne (One Acne™), sensitive skin, and acne-induced sequelae and describe the role of treatments in improving skin quality. Topical retinoids are considered the preferred first-line option for acne treatment by dermatologists, either as monotherapy or in combination with other treatments, because of their ability to target various aspects of the disease.

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  • Magnesium (Mg) is essential for many bodily functions and its levels need to be carefully controlled to prevent health issues.
  • Researchers created a computational model to study Mg homeostasis in male rats, linking it with an existing calcium (Ca) model to explore how Mg and Ca levels interact.
  • The model showed that a lack of dietary Mg led to very low Mg and mildly low Ca levels, while varying Ca intake affected Mg deficiency, and vitamin D deficiency significantly impacted Ca levels but had little effect on Mg.
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  • Mathematical models of whole-body dynamics help us understand how our body regulates essential physiological processes like metabolism and blood pressure, but they often use a "baseline" of a 35-year-old man weighing 70 kg.* -
  • This baseline model fails to represent many individuals, such as women, older adults, and those with different body weights, highlighting the need for more inclusive models that consider factors like sex, age, weight, and circadian rhythms.* -
  • The text emphasizes that personalized models can better explain physiological differences by using the blood pressure regulatory system as an example, showcasing the importance of capturing individual variations.*
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High Na intake has been linked to elevations in blood pressure, whereas K has the opposite effect. The underlying mechanisms involve complex interactions among renal function, fluid volume, fluid-regulatory hormones, the vasculature, cardiac function, and the autonomic nervous system. These mechanisms are likely moderated by sex, given the known sex differences in blood pressure regulation and the higher prevalence of hypertension in men.

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