Publications by authors named "A Lavie"
L-asparaginase (L-ASNase) is crucial in treating pediatric acute lymphoblastic leukemia (ALL), but its use is hampered by side effects from the immunogenicity and L-glutaminase (L-GLNase) co-activity of FDA-approved bacterial L-ASNases, often leading to treatment discontinuation and poor outcomes. The toxicity of these L-ASNases makes them especially challenging to use in adult cancer patients. To overcome these issues, we developed EBD-200, a humanized guinea pig L-ASNase with low Km and no L-GLNase activity, eliminating glutamine-related toxicity.
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- The study aimed to identify risk factors and create a predictive model for cesarean deliveries during labor in women with obesity.
- Researchers analyzed data from 5,663 women with a BMI of 30 or higher, finding that 7.5% ended up having a cesarean delivery.
- Key risk factors included age over 35, higher pre-gestational BMI, nulliparity, and certain medical interventions, with the predictive model showing 85% sensitivity and 70% specificity for predicting cesarean needs.
Risk factors for re-hospitalization following cesarean delivery at term.
Int J Gynaecol Obstet
November 2024
Objective: To identify the key risk factors contributing to re-hospitalization after term cesarean delivery (CD).
Methods: This retrospective cohort study included women who underwent CD at term at a university-affiliated tertiary medical center (January 2021 to March 2023). The primary outcome was risk factors for re-hospitalization within 30 days post-discharge.
Background: Neuraxial anesthesia is the preferred anesthesia mode for cesarean delivery (CD). The primary study aim was to study the rate of neuraxial anesthesia for cesarean delivery before and after educational strategies were implemented, focusing on neuraxial anesthesia use for CD.
Methods: We performed a retrospective analysis of the mode of anesthesia for CD.
Introduction: Prophylactic vasopressor administration reduces spinal hypotension during cesarean delivery, however the effects of vasopressor administration on neonatal acidemia remain uncertain. We examined the occurrence of neonatal acidemia in the setting of non-urgent cesarean delivery and compared outcomes between cases receiving prophylactic phenylephrine infusion versus cases treated with boluses of phenylephrine.
Methods: Retrospective cohort study with ethical approval, comparing non-urgent cesarean delivery cases performed under spinal anesthesia (2016 to 2021), receiving either prophylactic phenylephrine infusion or boluses as needed.