Publications by authors named "A Lapitz"
The proteomic analysis of serum extracellular vesicles (EVs) could be a useful tool for studying the pathophysiology of Crohn's disease (CD) and ulcerative colitis (UC), as well as for biomarker discovery. To characterize the proteomic composition of serum EVs in patients with CD and UC to identify biomarkers and molecular pathways associated with pathogenesis and activity. Methods: Serum EVs were enriched and analyzed in patients with quiescent CD, active CD (aCD), quiescent UC, active UC (aUC), and healthy controls (HCs) (n = 30 per group).
View Article and Find Full Text PDFBackground And Aims: Primary sclerosing cholangitis (PSC) is a chronic cholestatic liver disease characterised by progressive biliary inflammation and fibrosis, leading to liver cirrhosis and cholangiocarcinoma. GPBAR1 (TGR5) is a G protein-coupled receptor for secondary bile acids. In this study, we have examined the therapeutic potential of BAR501, a selective GPBAR1 agonist in a PSC model.
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- Metabolic dysfunction-associated steatotic liver disease (MASLD) is a serious liver condition that includes simple fat buildup in the liver (steatosis) and can progress to more severe forms, like metabolic dysfunction-associated steatohepatitis (MASH) and cirrhosis, affecting over a third of the population.* -
- The causes of MASLD are complex and involve factors like metabolism, environment, genetics, gut microbiota, and dysregulated lipid levels that lead to harmful fat and cell stress.* -
- This review focuses on how lipotoxicity contributes to the development of MASLD, detailing important lipid types and their effects, and exploring potential therapies to improve lipid metabolism and reduce liver damage.*
Background & Aims: Cholangiocarcinoma (CCA), heterogeneous biliary tumours with dismal prognosis, lacks accurate early diagnostic methods especially important for individuals at high-risk (i.e. those with primary sclerosing cholangitis [PSC]).
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