Publications by authors named "A Lamoureux"
Metastatic uveal melanoma is a rare disease with a poor prognosis. Usual treatments have not proven effective. Tebentafusp, a bispecific protein targeting melanoma cells and T lymphocytes, is the first approved treatment with a proven survival benefit in a randomized clinical.
View Article and Find Full Text PDFPurpose: TRK fusions are detected in less than 2% of central nervous system tumors. There are limited data on the clinical course of affected patients.
Experimental Design: We conducted an international retrospective cohort study of patients with TRK fusion-driven CNS tumors.
Background: Dorsomedian nasopharyngeal masses with benign macroscopic appearance are frequently observed during retrograde nasopharyngoscopy, particularly in brachycephalic breeds, but are not well described.
Hypothesis/objectives: To characterize these masses, assess their frequency, and identify the potential factors associated with their presence.
Animals: Dogs that underwent retrograde nasopharyngoscopy at a private hospital.
Time to use the right classification to predict the severity of checkpoint inhibitor-induced liver injury, as assessed for causality using the updated RUCAM.
Aliment Pharmacol Ther
December 2024
Article Synopsis
- - This study investigates the severity and characteristics of checkpoint inhibitor-induced hepatitis, a significant side effect of cancer immunotherapy, focusing on patients with severe liver injury (grade 3 and 4) based on the Common Terminology Criteria for Adverse Events (CTCAE).
- - A retrospective analysis of 100 patients revealed varying severity classifications and outcomes, indicating that the CTCAE may not effectively assess liver injury severity compared to hepatology-focused classification systems.
- - The findings suggest that using traditional hepatology scores could provide better insights and avoid issues like unnecessary steroid treatments and hindered re-administration of immune checkpoint inhibitors.