Publications by authors named "A Lalonde"
Article Synopsis
- Nitroso compounds (RNO) are byproducts of drug metabolism that interact with heme proteins, forming stable complexes which can serve as models for unstable heme-HNO intermediates critical in the nitrogen cycle.
- A series of six-coordinate ferrous heme-RNO complexes were synthesized and characterized using various methods, including nuclear resonance vibrational spectroscopy, shedding light on their vibrational properties compared to HNO analogs.
- While these complexes are stable and do not react with NO or exhibit significant reactivity with Lewis acids, their behavior indicates that they are unsuitable models for studying the reactivity of heme-HNO complexes.
Objective: To demonstrate that successful health systems strengthening (HSS) projects have addressed disparities and inequities in maternal and perinatal care in low-income countries.
Methods: A comprehensive literature review covered the period between 1980 and 2022, focusing on successful HSS interventions within health systems' seven core components that improved maternal and perinatal care.
Results: The findings highlight the importance of integrating quality interventions into robust health systems, as this has been shown to reduce maternal and newborn mortality.
Beam current transformers (BCT) are promising detectors for real-time beam monitoring in ultra-high dose rate (UHDR) electron radiotherapy. However, previous studies have reported a significant sensitivity of the BCT signal to changes in source-to-surface distance (SSD), field size, and phantom material which have until now been attributed to the fluctuating levels of electrons backscattered within the BCT. The purpose of this study is to evaluate this hypothesis, with the goal of understanding and mitigating the variations in BCT signal due to changes in irradiation conditions.
View Article and Find Full Text PDFBackground: Unusual olfactory perception, often referred to as "phantosmia" or "cacosmia" has been reported during brain radiotherapy (RT), but is infrequent and does not typically interfere with the ability to deliver treatment. We seek to determine the rate of phantosmia for patients treated with proton craniospinal irradiation (CSI) and identify any potential clinical or treatment-related associations.
Methods: We performed a retrospective review of 127 pediatric patients treated with CSI, followed by a boost to the brain for primary brain tumors in a single institution between 2016 and 2021.
. Clinical outcomes after proton therapy have shown some variability that is not fully understood. Different approaches have been suggested to explain the biological outcome, but none has yet provided a comprehensive and satisfactory rationale for observed toxicities.
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