Publications by authors named "A Lakshmi Pa"

Background Diabetes mellitus (DM) refers to a group of metabolic disorders that share the phenotype of hyperglycemia. "Diabetic nephropathy (DN)" is a microvascular complication of DM, and it is the leading cause of end-stage renal failure. Increased urinary albumin excretion (UAE) and a decrease in glomerular filtration rate (GFR) are associated with DN along with elevated blood pressure and end-stage renal disease (ESRD).

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There is a known relationship between Alzheimer's disease (AD) and Down syndrome (DS), with the latter typically developing AD-like neuropathology in mid-life. In order to further understand this relationship we examined intersectin-1 (ITSN1) and the regulator of calcineurin-1 (RCAN1), proteins involved in endosomal and lysosomal trafficking that are over-expressed in DS. We examined RCAN1 and ITSN1 levels (both long (-L) and short (-S) isoforms) and the level of endogenous metals in White Blood Cells (WBCs) collected from AD patients who were enrolled in the Australian Imaging, Biomarker and Lifestyle Study on Ageing (AIBL).

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The replacement of natural gas combustion for district heating by wood waste and wood pellets gasification systems with or without emission control has been investigated by a streamlined LCA. While stack emissions from controlled gasification systems are lower than the applicable regulations, compared to the current base case, 12% and 133% increases are expected in the overall human health impacts for wood pellets and wood waste, respectively. With controlled gasification, external costs and GHG emission can be reduced by 35% and 82% on average, respectively.

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After a fatal accident during the discharge of wood pellets at Helsingborg, emissions from pellets during marine transportation became a concern for the safe handling and storage of wood pellets. In this paper, a two-compartment model has been developed for the first time to predict the concentrations of CO, CO₂, CH₄, and O₂ inside the cargo ship and the time and rate of forced ventilation required before the safe entry into the stairway adjacent to the storage hatch. The hatch and stairway are treated as two perfectly mixed tanks.

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