Dissociated expression of Bcl-2 and Ki-67 in endometrial lesions: diagnostic and histogenetic implications.

The objective of the present study was to analyze the expression of the proliferation marker, Ki-67, and the anti-apoptotic protein, bcl-2, in various endometrial lesions. Ki-67 and bcl-2 expressions were studied in 194 specimens of endometrial hyperplasia, polyps, carcinomas, and cyclic endometrium from a defined geographic area. Results were statistically analyzed with respect to marker expression, localization to the stromal or glandular component, and intraglandular topography.

Transvaginal ultrasonography and endometrial histology in peri- and postmenopausal women on hormone replacement therapy.

Objective: To determine the association between endometrial thickness and endometrial histology in a large sample of women using HRT.

Design: Results from three multi-centre studies were combined.

Participants: Five hundred and sixty-four climacteric women were treated with either sequential, continuous combined or long-cycle therapy.

Seventeen year follow-up study of bone mass in patients with mild asymptomatic hyperparathyroidism some of whom were operated on.

Objective: To compare the effect of operation and observation on bone mineral mass in patients with mild asymptomatic hyperparathyroidism (HPT).

Design: A randomised 17-year follow-up study.

Setting: University hospital, Sweden.

Denser trabecular bone in women with endometrial carcinoma.

Bone mineral density (BMD) was measured in the distal radius of patients with endometrial carcinoma (EC). The patients were classified into two subgroups depending on whether earlier hormonal replacement therapy (HRT) was given. Two groups of women were recruited as controls: patients with post-menopausal bleeding for non-malignant reasons (hospital controls) and healthy women, free of gyn-ecologic symptoms (non-hospital controls).

Is there an altered steroid profile in patients with endometrial carcinoma?

Background: Besides the well-known association between endometrial carcinoma (EC) and unopposed estrogen, androgens also may play a role in this respect; however, previous studies on endogenous estrogens and androgens in patients with EC and control subjects have yielded mostly divergent results, probably because of the use of poorly defined control groups.

Methods: Circulating steroid and pituitary hormones and sex hormone-binding globulin were measured in patients with EC and matched control groups of either patients with nonmalignant postmenopausal bleeding (hospital control subjects) and healthy, symptom-free women (nonhospital control subjects).

Results: Patients with EC had higher serum levels of adrenal C21 and C19 steroids, estrogens, and biologically active testosterone than nonhospital control subjects, whereas the hospital control subjects constituted an intermediate group in this respect.