Characteristics and outcome of severe hypercalcemia on admission to the emergency department: a retrospective cohort study.

Aims Of The Study: To investigate the prevalence of hypercalcemia (>2.60 mmol/l) and severe hypercalcemia (≥2.80 mmol/l) on admission.

Thrombotic thrombocytopenic purpura associated to dual checkpoint inhibitor therapy for metastatic melanoma.

Dual checkpoint inhibitor therapy has known immune-related adverse events. However, checkpoint inhibitor-associated thrombotic thrombocytopenic purpura is very rarely reported. We present a case of a 70-year old man with advanced melanoma, presenting with severe thrombocytopenia, hemolytic anemia with schistocytes and suppressed ADAMTS-13 activity by ADAMTS-13 inhibitors.

B cell function after haploidentical in utero bone marrow transplantation in a patient with severe combined immunodeficiency.

An in utero paternal CD34(+) cell transplant was performed in a T-B+NK+ SCID fetus. We report here the results of the 3-year humoral immune reconstitution study. The methods used were ApoB VNTR typing, flow cytometry, nephelometry, hemagglutination, ELISA, ELISPOT and lymphoproliferative assays.