[A fatal course of Nelson syndrome].

An unusually therapy-resistant form of Nelson's syndrome developed in a 23-year-old woman two years after treatment of a pituitary-dependent Cushing's syndrome by bilateral adrenalectomy (1977). Removal of a corticotrophic adenoma by a first transsphenoidal pituitary operation (1979) brought only temporary relief. Two years later, regrowth and apoplexy of the pituitary adenoma led to oculomotor paralysis and had to be treated by a second transsphenoidal operation (1981).

[Old and new aspects of obesity].

Some decades ago clinicians accepted that, for a given height and weight, the amount of calories necessary to maintain a constant weight differed from one individual to another. There was no apparent explanation for these individual differences. Later, however, obesity was thought to be the consequence of overfeeding.