Publications by authors named "A La Greca"
Background: The management of high-surgical risk patients with moderate to severe acute cholecystitis is challenging in clinical practice. Early laparoscopic cholecystectomy is considered the gold standard for patients who do not respond to conservative treatment. However, for those unfit for surgery due to high-surgical risk, alternative treatment options such as percutaneous cholecystostomy (PC) are available.
View Article and Find Full Text PDFWe investigated if thyroid nodule taller-than-wide (TTW) feature and sphericity metrics are helpful in separating benign neoplastic thyroid nodules (follicular and oncocytic adenomas) from follicular thyroid carcinomas (FTC) and oncocytic thyroid carcinomas (OCA). This is a retrospective study of TTW sonographic feature as reported by radiologists and nodule sphericity metrics at two academic health systems. Surgical pathology reports for benign and malignant follicular and oncocytic neoplasms, non-neoplastic nodules (hyperplastic and adenomatoid), and classic papillary thyroid cancers (PTC) were extracted from enterprise data warehouses.
View Article and Find Full Text PDFBackground: Laparoscopic procedures have nowadays become the gold standard in multiple abdominal diseases, but in the emergency setting, especially in major surgery, laparoscopy still represents an obstacle for most surgeons. This multicentric study aims to define the surgical approach for emergency resective surgery in left colonic perforation peritonitis, determine the factors influencing the choice between MIS and open surgery, and identify factors associated with laparotomic conversion.
Methods: Retrospective data from 516 patients treated for left colonic perforation between January 2019 and December 2023 across six Italian centers was collected.
Article Synopsis
- * An analysis of ATMPs in Italy from 2016 to 2023 shows that while 9 of 18 authorized ATMPs are reimbursed by the Italian National Health System, only 6 have been used, leading to an expenditure of about 300 million euros, primarily due to CAR-T therapies.
- * Patient access to ATMPs takes an average of 340.6 days after reimbursement decisions, but since 2016, availability and treatment coverage have improved, with most regions having at least one authorized center for administering
MEN2 phenotype in a family with germline heterozygous rare RET K666N variant.
Endocrinol Diabetes Metab Case Rep
July 2024
Article Synopsis
- MEN2 is a hereditary cancer syndrome linked to mutations in the RET proto-oncogene, with MEN2A being the most common form, involving risks for medullary thyroid cancer, pheochromocytoma, and primary hyperparathyroidism.
- The specific RET variant K666N is rare, and most associated patients generally present with a mild form of medullary thyroid cancer; however, one case showed more severe symptoms including pheochromocytoma.
- A reported case involves a young proband who developed severe complications post-surgery, revealing a RET K666N variant alongside pheochromocytoma, medullary thyroid cancer, and primary hyperparathyroidism, indicating it may have low penetrance in MEN