Patch-seq of mouse DRG neurons reveals candidate genes for specific mechanosensory functions.

A variety of mechanosensory neurons are involved in touch, proprioception, and pain. Many molecular components of the mechanotransduction machinery subserving these sensory modalities remain to be discovered. Here, we combine recordings of mechanosensitive (MS) currents in mechanosensory neurons with single-cell RNA sequencing.

Prevalence of infection and antibiotic resistance profile in Armenia.

Background: The prevalence of infection was never assessed in Armenia, nor was the prevalence of resistance against the main antibiotics concerned, despite the fact that these data are fundamental to establish evidence-based recommendations for management of this infection. We aimed to fill this gap by assessing prevalence of among adult population in Armenia and resistance of strains to clarithromycin and levofloxacin.

Methods: seroprevalence was determined in 217 asymptomatic adult subjects submitted to a health checkup using an ELISA.

Healthcare access for deaf patients - The legal and ethical perspectives.

Deaf patients are too often overlooked in our society despite requiring in-depth attention to their specific communication needs. If they are not able to communicate with healthcare professionals, they may be unable to access and receive appropriate care. Yet, medical providers who fail to address patients' linguistic difficulties breach their ethical and professional duties, and face potential malpractice lawsuits.

Deregulation of MicroRNAs in Gastric Lymphomagenesis Induced in the d3Tx Mouse Model of Infection.

infection is considered as an excellent model of chronic inflammation-induced tumor development. Our project focuses on gastric MALT lymphoma (GML) related to infection and mediated by the chronic inflammatory process initiated by the infection. Recently, microRNAs (miRNAs) have emerged as a new class of gene regulators, which play key roles in inflammation and carcinogenesis acting as oncogenes or tumor suppressors.

A New Animal Model of Gastric Lymphomagenesis: APRIL Transgenic Mice Infected by Helicobacter Species.

APRIL is a member of the tumor necrosis factor cytokine family involved in the regulation of B-cell immunity. We present a study of the infection by Helicobacter species of transgenic (Tg) C57BL6 mice, ectopically expressing the human form of APRIL. Wild-type (WT) and APRIL Tg mice were infected with Helicobacter felis and Helicobacter pylori and compared with noninfected animals.