WhiA transcription factor provides feedback loop between translation and energy production in a genome-reduced bacterium.

Introduction: WhiA is a conserved protein found in numerous bacteria. It consists of an HTH DNA-binding domain linked with a homing endonuclease (HEN) domain. WhiA is one of the most conserved transcription factors in reduced bacteria of the class Mollicutes.

Homogeneous films from amphiphilic hyaluronan and their characterization by confocal microscopy and nanoindentation.

Self-supporting films from amphiphilic hyaluronan are suitable for medical applications like wound dressings or resorbable implants. These films are typically cast from water/alcohol solutions. However, when the mixed solvent evaporates in ambient air, convection flows develop in the solution and become imprinted in the film, potentially compromising its properties.

Pore-network extraction using discrete Morse theory: Preserving the topology of the pore space.

Pore-scale modeling based on the 3D structural information of porous materials has enormous potential in assessing physical properties beyond the capabilities of laboratory methods. Such capabilities are pricey in terms of computational expenses, and this limits the applicability of the direct simulations to a small volume and requires high-performance computational resources, especially for multiphase flow simulations. The only pore-scale technique capable of dealing with large representative volumes of porous samples is pore-network (PNM) based modeling.

Glibenclamide alters serotonin and dopamine levels in the rat striatum and hippocampus, reducing cognitive impairment.

Rationale: Glibenclamide (GD) is a widely used medical drug; therefore, identifying the mechanisms underlying its pleiotropic effects in the central nervous system is urgent.

Objectives: The aim of this work was to determine the ability of GD to modulate serotonin (5-hydroxytryptamine, 5-HT) and dopamine (DA) transmission and to assess the dose-dependent effect of GD on cognitive function in rats during natural ageing.

Methods: In Experiment 1, rats received 10, 25, or 50 μg/kg GD intraperitoneally for 10 days.

Thymidine utilisation pathway is a novel phenotypic switch of .

is a bacterium belonging to the class . It causes acute and chronic infections of the urogenital tract. The main features of this bacterium are an absence of cell wall and a reduced genome size (517-622 protein-encoding genes).