USP14 inhibits sensitization-mediated degradation of KDM4D to epigenetically regulate dendritic cell tolerogenic capacity and mitigates airway allergy.

Numerous immune disorders are caused by the dysfunction of dendritic cells (DC). The mechanism has not been fully comprehended yet. This research is designed to regulate the epigenetic status of lysine-specific demethylase 4D (KDM4D) to enhance DC's immune tolerogenic capacity.

Nano-arrayed CuS@MoS heterojunction SERS sensor for highly sensitive and visual detection of polystyrene in environmental matrices.

The burgeoning issue of micro/nanoplastics in ecosystems underscores an urgent need for advanced detection techniques. Herein, we introduce a novel SERS-based approach using a noble metal-free CuS@MoS heterojunction sensor, which has been meticulously engineered for enhanced sensitivity and stability in the detection of plastic contaminants. This semiconductor heterostructure harnesses the inherent surface plasmon resonance (SPR) effects of CuS and the efficient charge transfer facilitated by the built-in electric field at the CuS@MoS interface, rivaling the performance of noble-metal-based SERS sensors.

Analysis of influencing factors of psychological birth trauma among postpartum women in China: A multicenter cross-sectional study based on the ABC-X model.

Background: Little is known about the influencing factors of psychological birth trauma (PBT) among postpartum women in China.

Methods: A multicenter cross-sectional survey was conducted from April to June 2023 among 2230 women within one year postpartum by convenience sampling. The measurement tools were selected based on the classical ABC-X model.

Advantages and challenges of using allogeneic vs. autologous sources for neuronal cell replacement in Parkinson's disease: insights from non-human primate studies.

Intracerebral grafting of dopamine-producing cells is proposed as a strategy to replace the typical neurons lost to Parkinson's disease (PD) and improve the typical PD motor symptoms. Non-human primate studies have provided clues on the relationship between host's immune response and grafting success. Herein, we discuss how the host's immune system differentially affects the graft depending on the origin of the cells and reflect on the advantages and limitations of the immune paradigms utilized to assess graft-related outcomes.

Similar failures of consideration arise in human and machine planning.

Humans are remarkably efficient at decision making, even in "open-ended" problems where the set of possible actions is too large for exhaustive evaluation. Our success relies, in part, on processes for calling to mind the right candidate actions. When these processes fail, the result is a kind of puzzle in which the value of a solution would be obvious once it is considered, but never gets considered in the first place.