[Structural and functional changes of the loose connective tissue and macrophage system in experimental crush-syndrome].

Cells and the extracellular matrix of the loose connective tissue as well as the macrophage system were studied in experimental crush-syndrome in 50 rats using histological, histochemical and electron microscopical methods. The results of the investigation have shown that the components of the loose connective tissue and the macrophage system actively responded to 1-hour-long hindlimb compression. Severe structural and functional injury of the cells and extracellular matrix of the subcutaneous loose connective tissue and of the stroma of different organs (lung, heart, kidney) was detected on dayl, was especially pronounced on day 7 and partly regressed by day 30 after the decompression.

[The effects of trimetazidine on left ventricular function and physical exercise tolerance in patients with ischemic cardiomyopathy].

Trimetazidine is a new metabolic antiischemic agent, which increases the tolerance of cardiomyocytes to ischemia. The aim of the study was to evaluate the effect of additional trimatazidine therapy in patients with ischemic cardiomyopathy (ICMP) in comparison with standard therapy of cardiac insufficiency. According to the results of the study, trimetazidine improves the clinical status, functional class of cardiac insufficiency, left ventricular ejection fraction, in ICMP patients.