Publications by authors named "A L Sperling"
Vitiligo has a complex multifactorial etiology involving a T-cell mediated autoimmune response to cutaneous melanocytes. Microbial dysbiosis has been assigned a contributing role in vitiligo etiology. Treating vitiligo can be a challenging task and finding novel treatment approaches is crucial.
View Article and Find Full Text PDFThe urgent need for effective treatments for acute and chronic lung diseases underscores the significance of developing innovative preclinical human research tools. The 2023 ATS Workshop on Precision Cut Lung Slices (PCLS) brought together 35 experts to discuss and address the role of human tissue-derived PCLS as a unique tool for target and drug discovery and validation in pulmonary medicine. With increasing interest and usage, along with advancements in methods and technology, there is a growing need for consensus on PCLS methodology and readouts.
View Article and Find Full Text PDFFemale individuals have an increased prevalence of many Th17 cell-mediated diseases, including asthma. Androgen signaling decreases Th17 cell-mediated airway inflammation, and Th17 cells rely on glutaminolysis. However, it remains unclear whether androgen receptor (AR) signaling modifies glutamine metabolism to suppress Th17 cell-mediated airway inflammation.
View Article and Find Full Text PDFArticle Synopsis
- - The study explores the unique immune environment of the lungs, highlighting how different immune cells respond to activators, which is crucial for understanding asthma development and lung immunity.
- - Researchers isolated lung immune cells from six donors and evaluated their gene expression after exposure to various stimuli using advanced techniques like single-cell RNA sequencing.
- - Findings revealed significant changes in gene expression across different immune cell types, with a notable correlation to asthma-related genetic factors, emphasizing the role of lung B cells in expressing specific genes associated with asthma.