Publications by authors named "A L Speer"

The complexity of intestinal cytoarchitecture and function poses significant challenges for the creation of the bioengineered small intestine. Techniques for generating human intestinal organoids (HIOs) resembling human small intestine have been previously reported. HIOs contain epithelium and mesenchyme but lack other critical components of functional intestine such as the enteric nervous system (ENS), immune cells, vasculature, and microbiome.

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The purpose of the present meta-analysis was to determine if biodata scale scores differ based on demographic group membership (i.e., gender, race, age) and to evaluate the contextual factors that amplify or mitigate these effects (e.

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The escalating threat posed by antibiotic resistance is a global concern and underscores the need for new antibiotics. In this context, the recent discovery of evybactin, a nonribosomal depsipeptide antibiotic that selectively and potently inhibits the growth of M. tuberculosis, is particularly noteworthy.

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Article Synopsis
  • Human noroviruses (HuNoVs) are key contributors to diarrhea outbreaks worldwide, and studying them was difficult due to a lack of effective culture methods.
  • Recent advancements in cultivating various HuNoV strains in human intestinal enteroids (HIEs) have greatly improved research into their replication and disease mechanisms.
  • The research showed that different types of HIEs, particularly those from small intestines and genetically modified lines, have varying levels of susceptibility to HuNoV infection, revealing insights into how these viruses affect human health.
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Introduction: Enhanced Recovery After Surgery (ERAS) guidelines in adults have demonstrated reduced complications, length of stay, and cost. However, neonatal ERAS studies are limited and translation of adult ERAS guidelines to neonates is challenging. Furthermore, the knowledge, perception, and practice of neonatal ERAS guidelines is largely unknown.

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