Publications by authors named "A L Soilly"
Article Synopsis
- The Lungsco01 study is the first to evaluate the effectiveness and economic impact of video-thoracoscopy compared to open thoracotomy for treating non-small cell lung cancer in France, involving 259 patients from 10 medical centers over a four-year period.
- Results indicated that the average costs for open thoracotomy were lower than for video-thoracoscopy at both 30 days and 3 months post-surgery, with video-thoracoscopy showing a higher incremental cost-utility ratio per additional quality-adjusted life-year (QALY) gained.
- The analysis revealed a 64% probability that video-thoracoscopy was cost-effective at the 30-day mark
Article Synopsis
- The DiVa study is a randomised clinical trial focused on improving care for patients who have suffered a stroke, TIA, or myocardial infarction by comparing intensive multidisciplinary follow-up with standard care.
- The trial will include 1,720 patients across multiple hospitals and evaluate various outcomes, including cost-effectiveness and health impacts over two years.
- Key outcomes include the measurement of cost-utility and effectiveness in reducing complications and improving quality of life, along with further analysis on factors affecting the success of the proposed follow-up approach.
Background: With the development of next generation sequencing technologies in France, exome sequencing (ES) has recently emerged as an opportunity to improve the diagnosis rate of patients presenting an intellectual disability (ID). To help French policy makers determine an adequate tariff for ES, we aimed to assess the unit cost per ES diagnostic test for ID from the preparation of the pre-analytical step until the report writing step and to identify its main cost drivers.
Methods: A micro-costing bottom-up approach was conducted for the year 2018 in a French setting as part of the DISSEQ study, a cost-effectiveness study funded by the Ministry of Health and performed in collaboration with the GAD (Génétique des Anomalies du Développement), a genetic team from the Dijon University Hospital, and a public sequencing platform, the Centre National de Recherche en Génomique Humaine (CNRGH).
The Economic, Medical and Psychosocial Consequences of Whole Genome Sequencing for the Genetic Diagnosis of Patients With Intellectual Disability: The DEFIDIAG Study Protocol.
Front Genet
April 2022
Like other countries, France has invested in a national medical genomics program. Among the four pilot research studies, the DEFIDIAG project focuses on the use of whole genome sequencing (WGS) for patients with intellectual disability (ID), a neurodevelopmental condition affecting 1-3% of the general population but due to a plethora of genes. However, the access to genomic analyses has many potential individual and societal issues in addition to the technical challenges.
View Article and Find Full Text PDFObjective: This pragmatic, multicenter, open-label, randomized controlled trial (RCT) aimed to compare the effectiveness, safety, and cost-utility of a custom-made knee brace versus usual care over 1 year in medial knee osteoarthritis (OA).
Design: 120 patients with medial knee OA (VAS pain at rest >40/100), classified as Kellgren-Lawrence grade II-IV, were randomized into two groups: ODRA plus usual care (ODRA group) and usual care alone (UCA group). The primary effectiveness outcome was the change in VAS pain between M0 and M12.