Publications by authors named "A L Soccio"
Article Synopsis
- The LRRK2 gene is crucial for understanding familial Parkinson's disease as it is the major genetic factor associated with the condition.
- LRRK2 is involved in various cellular signaling pathways and is primarily found in the presynaptic compartment, where it plays a role in managing vesicle trafficking and neurotransmitter release.
- Research using LRRK2 knockout mice revealed that the absence of LRRK2 leads to significant deficits in olfactory behavior and alters critical neuronal network dynamics, particularly affecting gamma rhythms and response to odors during active sensory processing.
Relational information about items in memory is thought to be represented in our brain thanks to an internal comprehensive model, also referred to as a "cognitive map". In the human neuroimaging literature, two signatures of bi-dimensional cognitive maps have been reported: the grid-like code and the distance-dependent code. While these kinds of representation were previously observed during spatial navigation and, more recently, during processing of perceptual stimuli, it is still an open question whether they also underlie the representation of the most basic items of language: words.
View Article and Find Full Text PDFBackground: Natural rubber latex (NRL) allergy is a worldwide problem. Although prevention is sufficient to reduce sensitization, prolonged avoidance is needed to prevent resensitization or adverse reactions on re-exposure.
Objectives: This double-blind, placebo-controlled study was conducted to determine the efficacy of sublingual immunotherapy (SLIT) with latex.
Background: Delayed pressure urticaria (DPU) comes under the heading of physical urticaria. Characteristically itchy, tender or painful weals occur at sites of local pressure including the waistband, soles of the feet and palms of the hands. Lesion onset is typically 3-12 h after the application of pressure, and lesions may persist for more than 24 h.
View Article and Find Full Text PDFBackground: Natural rubber latex is a frequent cause of IgE-mediated allergy in hairdressers; but a non-IgE-mediated allergy to latex proteins can also occur. Sixty-one hairdressers, reporting latex glove-related symptoms, were enrolled in the study.
Methods: They were evaluated for latex allergy by assessment of serum specific IgE and skin prick tests.