Permeation-Enhancing Strategies for Transdermal Delivery of Cannabinoids.

This review aims to provide an overview of the advancements and status of clinical studies and potential permeation-enhancing strategies in the transdermal delivery of cannabinoids. A systematic and comprehensive literature search across academic databases, search engines, and online sources to identify relevant literature on the transdermal administration of cannabinoids. Cannabinoids have proven beneficial in the treatment of wide-ranging physical and psychological disorders.

Re-Examination of the NO + O Reaction.

The reaction of NO with O is a key step in consumption of nitrous oxide in thermal processes. It has two product channels, NO + NO (R2) and N + O (R3). The rate constant for R2 has been measured both in the forward and the reverse direction at elevated temperature and is well established.

Scalable Synthetic Route to PDMS Ring Polymers in High Yields from Commercially Available Materials Using the Piers-Rubinsztajn Reaction.

While cyclic polymers have intrigued researchers for their novel set of architecture-driven rheological interactions, the possibility of incorporating them in topological systems has been limited by the availability of large ring polymers. Thus, the need for scalable methods to produce ring polymers has become apparent. Here, a facile method to prepare polysiloxane ring polymers by means of Piers-Rubinsztajn chemistry is presented.

A reliable quantitative method for determining CBD content and release from transdermal patches in Franz cells.

Introduction: There are several cannabidiol (CBD) transdermal patches available on the market. However, none are FDA-approved. Furthermore, not much evidence has been published about CBD release and skin permeation from such patches, so the effectiveness and reliability remain unclear.

Crosslinking Methodology for Imidazole-Grafted Silicone Elastomers Allowing for Dielectric Elastomers Operated at Low Electrical Fields with High Strains.

For improved actuation at low voltages of dielectric elastomers, a high dielectric permittivity has been targeted for several years but most successful methods then either increase the stiffness of the elastomer and/or introduce notable losses of both mechanical and dielectric nature. For polydimethylsiloxane (PDMS)-based elastomers, most high-permittivity moieties inhibit the sensitive platinum catalyst used in the addition curing scheme. In contrast to the classical addition curing pathway to prepare PDMS elastomers, here, an alternative strategy is reported to prepare PDMS elastomers via the crosslinking reaction between multifunctional imidazole-grafted PDMS with difunctional bis(1-ethylene-imidazole-3-ium) bromide ionic liquid (bis-IL).