Unveiling the guardians of the genome: The dynamic role of histones in DNA organization and disease.

Histones are positively charged proteins found in the chromatin of eukaryotic cells. They regulate gene expression and are required for the organization and packaging of DNA within the nucleus. Histones are extremely conserved, allowing for transcription, replication, and repair.

Toxicity assessment of Oreochromis mossambicus exposed to carbamazepine and selenium: Physiological and genotoxic approach.

Although the toxicity of selenium (Se) and carbamazepine (CBZ) has already been demonstrated, the possible effects of freshwater fish co-exposure to these pollutants have not been explored. Thus, we aimed to evaluate the potential impact of Se and CBZ (alone and combined) exposure (both 5 µg/L) in Oreochromis mossambicus after 28 days. Exposure to CBZ, alone or combined with Se, significantly increases the "red blood cells" and "mean corpuscular volume.

Ecotoxicological Research on the Toxic Impact of Zinc Oxide and Silver Nanoparticles on Oreochromis mossambicus.

Silver nanoparticles (AgNPs) and Zinc oxide nanoparticles (ZnONPs) have been widely used and are eventually been discharged into the natural aquatic ecosystem. The current study examined and correlated the toxicity of AgNPs and ZnONPs on the Mozambique tilapia, Oreochromis mossambicus. Lethal concentration (LC) was determined with four different concentrations (0.

Toxicological study on ibuprofen and selenium in freshwater mussel Lamellidens marginalis and exploring the microbial cytochrome through modelling and quantum mechanics approaches for its toxicity degradation in contaminated environment.

Toxicological stress in aquatic organisms is caused by the discharge of hundreds of toxic pollutants and contaminants among which the current study concentrates on the toxic effect of non-steroidal anti-inflammatory drug ibuprofen (IBF) and the trace element selenium (Se). In this study, IBF and Se toxicity on freshwater mussel Lamellidens marginalis was studied for 14 days, and in silico predictions for their degradation were made using Molecular modelling and Quantum Mechanical approaches. The degrading propensity of cytochrome c oxidase proteins from Trametes verticillatus and Thauera selenatis (Turkey tail fungi and Gram-negative bacteria) is examined into atom level.

Blindness and ophthalmoplegia from metastatic breast carcinoma.

We report a very rare complication from metastatic breast cancer of right-sided blindness and ophthalmoplegia in a 70-year-old female. Cavernous sinus syndrome, superior orbital fissure syndrome and complicated sinusitis were considered in the differential diagnosis but involvement of cranial nerves II, III, IV, VI and the ophthalmic division of V were consistent with an orbital apex syndrome. She had been diagnosed with breast carcinoma 10 years previously.