Purpose: Asprosin, an orexigenic hormone that stimulates hepatic glucose release, is elevated in insulin resistance and associated with obesity. Plasma asprosin concentrations may also be related to female sex hormone levels; higher levels are reported in women with polycystic ovary syndrome (PCOS) but this may be related to peripheral insulin resistance also associated with PCOS. Clarification of female-specific factors influence on the plasma asprosin response is crucial for studies investigating asprosin.
View Article and Find Full Text PDFThe purpose was to determine the physiological correlates to cycling performance within a competitive paratriathlon. Five wheelchair user and ten ambulant paratriathletes undertook laboratory-based testing to determine their: peak rate of oxygen uptake; blood lactate- and ventilatory-derived physiological thresholds; and, their maximal aerobic power. These variables were subsequently expressed in absolute (l∙min or W), relative (ml∙kg∙min or W∙kg ) and scaled relative (or ml∙kg ∙min , ml∙kg ∙min or W∙kg ) terms.
View Article and Find Full Text PDFNumerous assays are available for the pharmacokinetic study of morphine. Two of these methods are compared with a new assay procedure, which involves a solid-phase extraction to clean up human plasma before radioimmunoassay allowing the determination of morphine levels to a sensitivity of 1 mugl(-1). Data are presented to show the importance of correct method choice if clinical studies are to be used in pharmacokinetic interpretations.
View Article and Find Full Text PDF