Effect of arm ergometer versus stabilization exercises on trunk control and pper extremity functions in children with diplegia: a randomized controlled trial.

Background: One of the most prevalent clinical subtypes of cerebral palsy (CP) is diplegia. Most children with diplegia have weakness in axial muscles and spasticity in extremities which have adverse impacts on trunk control and manual coordination of upper extremities.

Aim: To examine and compare between the effects of arm ergometer and stabilization exercises applied for duration of 12 weeks on upper extremity functioning, trunk control, and hand grip strength (HGS) in children with spastic diplegia.

Morphometric analysis of atlas lateral mass in Down syndrome cases with relevance to surgical intervention.

Purpose: Surgical stabilization of the Atlas vertebrae is indicated for severe atlantoaxial instability (AAI) in patients with Down syndrome (DS). This study aims to evaluate the morphological characteristics of the Atlas lateral mass (ALM) in patients with DS with regard to safe instrumentation for surgical stabilization and to compare them with non-syndromic group.

Methods: This multicenter, retrospective, case-control study included age- and sex-matched patients with and without DS aged > 7 years with a cervical computed tomography (CT) scan.

Revolutionizing Playing with Skeleton Atoms: Molecular Editing Surgery in Medicinal Chemistry.

Finding the most perfect drug candidates in the fields of drug discovery and medicinal chemistry will remain the main interest of drug designers. This concern necessitates organic and medicinal chemists, in most examples, to precisely design and search for drug candidates that are very analogous to the present effective drugs with solving, mainly, their proven critical pharmacological and clinical issues through slightly changing one or two atoms of the principal functional skeletons of the molecules of these present therapeutics by atom swapping, removal, and/or addition procedures in organic chemical synthesis. This accurate modern chemicosimilarity tactic in drug discovery surely saves time while keeping us very close, or sometimes highly superior, to the parent pharmacophoric bioactivity (i.

Diseases diagnosis based on artificial intelligence and ensemble classification.

Background: In recent years, Computer Aided Diagnosis (CAD) has become an important research area that attracted a lot of researchers. In medical diagnostic systems, several attempts have been made to build and enhance CAD applications to avoid errors that can cause dangerously misleading medical treatments. The most exciting opportunity for promoting the performance of CAD system can be accomplished by integrating Artificial Intelligence (AI) in medicine.