Unbiased Drug Target Prediction Reveals Sensitivity to Ferroptosis Inducers, HDAC and RTK Inhibitors in Melanoma Subtypes.

Background: The utilization of PD1 and CTLA4 inhibitors has revolutionized the treatment of malignant melanoma (MM). However, resistance to targeted and immune-checkpoint-based therapies still poses a significant problem.

Objective: Here, we mine large-scale MM proteogenomic data to identify druggable targets and forecast treatment efficacy and resistance.

Co-evolution of behaviour and beliefs in social dilemmas: estimating material, social, cognitive and cultural determinants.

Understanding and predicting human cooperative behaviour and belief dynamics remains a major challenge both from the scientific and practical perspectives. Because of the complexity and multiplicity of material, social and cognitive factors involved, both empirical and theoretical work tends to focus only on some snippets of the puzzle. Recently, a mathematical theory has been proposed that integrates material, social and cognitive aspects of behaviour and beliefs dynamics to explain how people make decisions in social dilemmas within heterogeneous groups.

Ontogeny and function of the intestinal epithelial and innate immune cells during early development of chicks: to explore in ovo immunomodulatory nutrition.

Intestinal epithelial cells (IECs) and innate immune cells in the gastrointestinal tract (GIT) of chickens play crucial roles in pathogens defense and maintaining gut health. However, their effectiveness influenced with their developmental and functional stages during pre and post hatch periods of chick. During embryonic development, differentiation and migration of these innate immune systems are tightly regulated by diverse cellular and molecular factors.

Bentayga-I: Development of a Low-Cost and Open-Source Multispectral CubeSat for Marine Environment Monitoring and Prevention.

CubeSats have emerged as a promising alternative to satellite missions for studying remote areas where satellite data are scarce and insufficient, such as coastal and marine environments. However, their standard size and weight limitations make integrating remote sensing optical instruments challenging. This work presents the development of Bentayga-I, a CubeSat designed to validate PANDORA, a self-made, lightweight, cost-effective multispectral camera with interchangeable spectral optical filters, in near-space conditions.

Diverse phage communities are maintained stably on a clonal bacterial host.

Bacteriophages are the most abundant and phylogenetically diverse biological entities on Earth, yet the ecological mechanisms that sustain this extraordinary diversity remain unclear. In this study, we discovered that phage diversity consistently outstripped the diversity of their bacterial hosts under simple experimental conditions. We assembled and passaged dozens of diverse phage communities on a single, nonevolving strain of until the phage communities reached equilibrium.