The 'propofol infusion syndrome': the facts, their interpretation and implications for patient care.

AstraZeneca (the manufacturer of Diprivan) presents its review of the history of the so-called 'propofol infusion syndrome', highlighting the difficulties in analysing the incomplete information available. Theories as to its causality are presented and discussed; these include mitochondrial toxicity, mitochondrial defects, impaired tissue oxygenation and carbohydrate deficiency. A review of published and confidential safety data is presented and discussed; it concludes that the major risk factors for its development appear to be poor oxygen delivery, sepsis, serious cerebral injury and high propofol dosage.

Contractile properties and ultrastructure of three types of muscle fibre in the dogfish myotome.

Three main types of fibre can be differentiated in the adult dogfish myotome at the immediate post-anal level. An outer band of muscle consists of 80-90 pale multiply innervated fibres (superficial fibres). These fibres are 80-90 micron in diameter, lack M-lines and have a low Ca2+-activated myosin ATPase activity.