Antibacterial activity of withanolides, labdane glucosides, flavonoids and other constituents from two populations of Physalis patula.

Two populations of Physalis patula Miller collected in different localities (Querétaro and Teotihuacán) of Central México were analyzed. Eight new compounds including three withanolides, physapatolides A-C (1-3), two labdanes, 12-epi-physacoztomatin (10) and physapatulone (12), besides three 12-O-glucosyl labdanes, patulosides A-C (13-15), were isolated from these collections. A series of known withanolides, flavonoids, labdanes, sucrose esters, and sterols were also isolated.

Lactols from Physalis grisea.

From the extracts of stems and leaves as well as of calyxes of Physalis grisea were isolated four withalactols, the new griselactols A (3) and B (6) and the known physapubescin (1) and peruvianolide E (2). Other four known compounds were also isolated, kaempferol 3-O-β-sophoroside (5) and three sterols. The structures of compounds were elucidated by extensive spectroscopic data analyses, chemical and physical-chemical methods, including electronic circular dichroism (ECD), and by comparison with data described in the literature.

Sucrose esters from the calyxes of Physalis chenopodifolia.

Three new sucrose esters, physachenoses A-C (1-3) and the known withanolide, physachenolide D (4), were isolated from the calyxes of Physalis chenopodifolia Lam. Analysis of the MS, 1D and 2D NMR spectra of the new compounds allowed to determine their structures as 3'-O-dodecanoyl-2,3,4-tri-O-isobutyrylsucrose (1), 3'-O-dodecanoyl-2,4-di-O-isobutyryl-3-O-2-methylbutanoylsucrose (2), and 3'-O-dodecanoyl-2-O-isobutyryl-3-O-2-methylbutanoylsucrose (3).

Labdanes, Withanolides, and Other Constituents from .

Chemical investigation of the aerial parts (except fruits and calixes) of var. led to the isolation of a series of new labdane-type diterpenoids, including the closely related compounds -, the labdane glucosides and , a mixture of the epimeric alcohols and , and one labdanetriol, isolated as its tri--acetyl derivative . In addition, three new withanolides (-) and six known compounds were isolated.