Publications by authors named "A L OE Engsbro"
Background: Pediatric-onset ulcerative colitis (pUC) represents a more aggressive disease phenotype compared with adult-onset UC. We hypothesized that this difference can, in part, be explained by the composition of the microbiota.
Methods: In a prospective, longitudinal study, we included pediatric (N = 30) and adult (N = 30) patients with newly or previously (>1 year) diagnosed UC.
Diarrheal diseases caused by enteric pathogens are a significant public health concern. It is widely considered that close contact between persons, poor hygiene, and consumption of contaminated food are the primary causes of gastroenteritis. Clinical microbiology laboratory observations indicate that the incidence of enteropathogenic microorganisms may have been reduced in Denmark during the COVID-19 pandemic.
View Article and Find Full Text PDFThe effect of changing diagnostic method from culture to PCR on the number of episodes of human campylobacteriosis in Denmark: a retrospective study (2015-2022).
Microbiol Spectr
January 2024
This study is important because it shows the potential epidemiological silence associated with the use of culture as the primary diagnostic method for the laboratory identification of human campylobacteriosis. Also, we show how polymerase chain reaction methods are associated with a systematic increase in the number of human campylobacteriosis episodes as reported by routine disease surveillance. These findings are operationally relevant and have public health implications because they tell how crucial it is to consider changes in diagnostic methods, e.
View Article and Find Full Text PDFBetween November and December 2021, the first ever recorded outbreak of enteroinvasive in Denmark occurred at national scale. We describe the investigation of this outbreak, which was initially recognised in early December 2021. A total of 88 cases (58 female; 30 male) with a median age of 52 years (range: 0-91) were detected by PCR-based diagnostic methods.
View Article and Find Full Text PDFArticle Synopsis
- A study in Denmark examined the incidence of various enteric pathogens in 2018, revealing important gaps in surveillance for certain pathogens linked to acute gastroenteritis.
- Bacterial infections had the highest incidence rate, particularly among the population, while viral infections were predominantly seen in very young children and the elderly, indicating a demographic disparity.
- The research highlighted significant differences in diagnostic methods across the country, with PCR testing yielding higher detection rates compared to traditional culture and other methods, which is essential for accurately interpreting epidemiological data.