A Modification of the Quad Helix: The "Bi Helix".

Aim And Background: The quad helix is well known for its ability to treat posterior crossbites in children with maxillary deficiency. A few authors have also used it for the treatment of unilateral crossbite due to unilateral maxillary deficiency by incorporating modifications in the appliance. The aim was to treat a unilateral crossbite using a newly modified quad helix.

Short- versus standard-course antibiotic therapy for urinary tract infection in children: a systematic review and meta-analysis.

Background: Urinary tract infections are prevalent among children and are responsible for a significant healthcare burden. Antibiotic therapy is the cornerstone of treatment, but the optimal treatment duration remains elusive.

Objectives: This systematic review and meta-analysis aimed to explore the optimal duration of antibiotic therapy for urinary tract infection (UTI) in pediatric patients.

Chromothripsis-mediated small cell lung carcinoma.

Small cell lung carcinoma (SCLC) is a highly aggressive malignancy that is typically associated with tobacco exposure and inactivation of RB1 and TP53 genes. Here we performed detailed clinicopathologic, genomic and transcriptomic profiling of an atypical subset of SCLC that lacked RB1 and TP53 co-inactivation and arose in never/light smokers. We found that most cases were associated with chromothripsis - massive, localized chromosome shattering - recurrently involving chromosomes 11 or 12, and resulting in extrachromosomal (ecDNA) amplification of CCND1 or co-amplification of CCND2/CDK4/MDM2, respectively.