Publications by authors named "A L Mulyukin"

Article Synopsis
  • The study investigates how a small antibiotic-insensitive group of bacteria survives prolonged exposure to the antibiotic moxifloxacin, emphasizing the influence of factors like antibiotic concentration, growth stage, and potassium availability.
  • Results show that bacterial responses vary significantly: mid-logarithmic cultures can regrow after initial killing by moxifloxacin, while stationary-phase cultures may experience gradual killing in potassium-deficient conditions.
  • Electron microscopy reveals that bacteria in aggregates resist destruction longer than singular cells, and survivors exhibit diverse cell morphologies, suggesting varied responses to the same antibiotic dose based on the bacteria's physiological state.
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Alkanotrophic Rhodococcus strains from the Regional Specialised Collection of Alkanotrophic Microorganisms (acronym IEGM, www.iegmcol.ru) were screened for accumulation and sorption of MoO ions.

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Introduction: The increasing use of non-steroidal anti-inflammatory drugs (NSAIDs) has raised concerns regarding their environmental impact. To address this, understanding the effects of NSAIDs on bacteria is crucial for bioremediation efforts in pharmaceutical-contaminated environments. The primary challenge in breaking down persistent compounds lies not in the biochemical pathways but in capacity of bacteria to surmount stressors.

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has recently emerged as the cause of an increasing number of human infections worldwide. Unfortunately, it is highly resistant to existing drugs, and new specific agents to combat have not yet been found. The discovery of antibiotics that are effective not only against replicating but also against dormant and often recalcitrant cells is a daunting challenge.

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Efficient DNA sample preparation from fungi with the rigid cell walls is still critical for successful polymerase chain reaction (PCR), one of the basic platforms in molecular diagnostics of fungi, especially in medical mycology. Common methods that involve different chaotropes to yield DNA samples have found a limited application for fungi. Here we describe a novel procedure for efficient production of permeable fungal cell envelopes with DNA inside as suitable templates for PCR.

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