The Telomeric Repeats of HHV-6A Do Not Determine the Chromosome into Which the Virus Is Integrated.

Human herpes virus 6A (HHV-6A) is able to integrate into the telomeric and subtelomeric regions of human chromosomes representing chromosomally integrated HHV-6A (ciHHV-6A). The integration starts from the right direct repeat (DR) region. It has been shown experimentally that perfect telomeric repeats (pTMR) in the DR region are required for the integration, while the absence of the imperfect telomeric repeats (impTMR) only slightly reduces the frequency of HHV-6 integration cases.

[Clinical laboratory characteristics of serous meningitides in Saint Petersburg].

Four hundred and sixty-seven cases of serous meningitides that had occurred in 2007 and 2009, verified by the standard virological techniques: polymerase chain reaction, enzyme immunoassay, and complement-binding reaction, were analyzed. The authors ascertained the following features: the shift of the morbidity peak to autumn and winter months, the preponderance of ECHO enterovirus serotypes 6, 11, and 30 among the pathogens, the onset of meningitis masking various diseases, multiple organ dysfunction with a predominance of central nervous system changes and with the involvement of the cardiovascular system.

[The use of a modified complement fixation reaction for the rapid diagnosis of viral infections in children].

A system of diagnostic tests (complement enzyme assay) is developed, detecting viral and other antigens, toxins, antibodies, and specific immune complexes in liquid enzyme immunoassay based on the complement fixation test. The system is simple and economic, the results can be transferred into digital data, and the above factors can be detected individually in biological materials from patients. The system is effective, and in many cases (for example, in the diagnosis of enteroviral diseases) is the only method for rapid isolation and typing of the infection agents.