Impact of β-Carotene Enrichment on Carotenoid Composition and Gene Expression in Metanauplii.

Background: Carotenoids play essential nutritional and physiological roles in aquatic animals. Since aquatic species cannot synthesize carotenoids de novo, they must obtain these compounds from their diet to meet the physiological and adaptive requirements needed in specific aquaculture stages and conditions. Carotenoid supplementation in represents a promising strategy to enhance pigmentation, health, and growth in aquaculture species, particularly in larvae and other early developmental stages.

Use of Public Research and Manufacturing Enterprises to Lower Prescription Drug Prices and Increase Innovation.

This article proposes building on the success of publicly funded drug research and development and expanding the model to include the full cycle development, testing, manufacture and distribution of innovative and affordable new drugs.

Barriers to the Implementation of Max-Profit and Stochastic Feed Formulation Strategies: A Survey of the Australian Poultry Industry.

A survey of industry groups including nutritionists, producers, feed manufacturers, and technical personnel in broiler and layer operations within the Australian poultry industry was completed to determine the industry's present views of max-profit and stochastic feed formulation and the barriers they see to implementing these techniques. A total of 32 responses were collected, made up of 17 nutritionists, 4 feed manufacturers, 5 producers, and 6 technical personnel. The survey revealed interest and need to implement stochastic and max-profit feed formulation techniques and identified the key barriers to the implementation of these feed formulation techniques.

British Cardiovascular Intervention Society Training Culture Focus Group Position Statement: Bringing Trainees and Trainers Together.

Unprofessional behaviour within cardiology has been well documented and commonly occurs within the cardiac catheterisation laboratory, with higher rates in interventional subspecialities. While most trainees have positive experiences and encounters within the catheterisation laboratory, around one in five report experiencing bullying. This not only has a significant negative impact on the individuals directly involved, but also on the wider multidisciplinary team; importantly, it will have a deleterious effect on patient safety.

Multi-organ gene expression analysis and network modeling reveal regulatory control cascades during the development of hypertension in female spontaneously hypertensive rat.

Hypertension is a multifactorial disease with stage-specific gene expression changes occurring in multiple organs over time. The temporal sequence and the extent of gene regulatory network changes occurring across organs during the development of hypertension remain unresolved. In this study, female spontaneously hypertensive (SHR) and normotensive Wistar Kyoto (WKY) rats were used to analyze expression patterns of 96 genes spanning inflammatory, metabolic, sympathetic, fibrotic, and renin-angiotensin (RAS) pathways in five organs, at five time points from the onset to established hypertension.