Publications by authors named "A L Mazin"
Homologous recombination (HR) is a highly conserved tool for the removal of DNA double-strand breaks (DSBs) and the preservation of stalled and damaged DNA replication forks. Successful completion of HR requires the tumor suppressor BRCA2. Germline mutations in BRCA2 lead to familial breast, ovarian, and other cancers, underscoring the importance of this protein for maintaining genome stability.
View Article and Find Full Text PDFRAD54L is a DNA motor protein with multiple roles in homologous recombination DNA repair. In vitro, RAD54L was shown to also catalyze the reversal and restoration of model replication forks. In cells, however, little is known about how RAD54L may regulate the dynamics of DNA replication.
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- - The process of DNA double-strand break repair through homologous recombination requires end resection to create a single-stranded DNA template, involving the RAD51 recombinase and other proteins, with BRCA1-BARD1 being crucial for this step.
- - DNA end resection is performed by three key nucleases: EXO1, DNA2 (in partnership with BLM or WRN helicases), working together to resect the DNA ends, while BRCA1-BARD1’s role in regulating this process is critically examined.
- - Research shows that BRCA1-BARD1 directly interacts with EXO1, BLM, and WRN, enhancing their activity, and certain BARD1 mutations impairing DNA
RAD54L is a DNA motor protein with multiple roles in homologous recombination DNA repair (HR). , RAD54L was shown to also catalyze the reversal and restoration of model replication forks. In cells, however, little is known about how RAD54L may regulate the dynamics of DNA replication.
View Article and Find Full Text PDFHomologous recombination (HR) fulfils a pivotal role in the repair of DNA double-strand breaks and collapsed replication forks. HR depends on the products of several paralogues of RAD51, including the tetrameric complex of RAD51B, RAD51C, RAD51D and XRCC2 (BCDX2). BCDX2 functions as a mediator of nucleoprotein filament assembly by RAD51 and single-stranded DNA (ssDNA) during HR, but its mechanism remains undefined.
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