[Imbalance of T lymphocyte subpopulations in patients with psoriasis and its immune correction].

We investigated the levels of T-lymphocytes and their subpopulations-T-helper cells (TH) and T-suppressor cells (TS)-in the peripheral blood of 57 patients suffering from various clinical forms of psoriasis. Considerable decrease of the TH/TS rate (0.2 to 1.

[Clinicopathogenetic significance of K and NK blood lymphocytes in psoriasis].

The activity of killer lymphocytes and natural killer cells was impaired in the peripheral blood especially of such patients whose psoriasis was progressive or resistant to therapy.

[Treatment of congenital erythroderma ichthyosiforme in mother and son with the oral aromatic retinoid Ro 10-9359. The need for maintenance therapy].

Aromatic retinoid Ro 10-9359 (Tigason) administered in the doses 25-50 mg daily to two patients (mother and son) suffering from congenital non-bullous ichthyosiform erythroderma revealed complete disappearance of the clinical signs of the disease within two weeks. A relapse was noted in one patient 1.5 months after oral treatment was discontinued.

[Comparison of RePUVA and aromatic retinoid Ro 10-9359 with methotrexate in severe forms of psoriasis].

Treatment of 20 PUVA-resistant patients with aromatic retinoid Ro 10-9359 resulted in a considerable improvement of psoriasis up to total recovery, and potentiated a favorable clinical effect of subsequent PUVA-treatment with reduced 8-MOP dosage. Aromatic retinoid was especially effective in patients with psoriatic eruptions on palms, soles, face, and scalp. The combination of aromatic retinoid with methotrexate was successfully used in the treatment of two patients with a particularly severe course of psoriasis, one having psoriatic erythroderma coupled with psoriatic arthritis and the other psoriatic erythroderma.