Publications by authors named "A L Marson"
The ability of cells to maintain distinct identities and respond to transient environmental signals requires tightly controlled regulation of gene networks. These dynamic regulatory circuits that respond to extracellular cues in primary human cells remain poorly defined. The need for context-dependent regulation is prominent in T cells, where distinct lineages must respond to diverse signals to mount effective immune responses and maintain homeostasis.
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- T cell therapies, like CAR and TCR T cells, are emerging cancer treatments, but improving their effectiveness requires understanding their behavior in populations.
- The authors developed advanced tools using live-cell imaging to track and analyze modified T cells interacting with tumor cells, focusing on their morphology, movement, and interactions.
- They found that specific genetic modifications in TCR T cells led to longer interaction times and better activation against cancer cells, while other modifications increased T cell growth, paving the way for more effective cancer therapies.
Vitamin A deficiency (VAD) impacts over 50% of children aged 6-59 months in sub-Saharan Africa, causing severe health issues. Despite the importance of vitamin A supplementation (VAS) programs, barriers limit their effectiveness, making it essential to understand these factors for better outcomes. This systematic review aimed to identify the barriers and facilitators to VAS programs in Africa, using the Consolidated Framework for Implementation Research (CFIR) to conceptualize the findings.
View Article and Find Full Text PDFBackground: Progressive multifocal leukoencephalopathy (PML) is a frequently fatal disease of the central nervous system caused by JC virus (JCV). Survival is dependent on early diagnosis and ability to re-establish anti-viral T cell immunity. Adoptive transfer of polyomavirus-specific T cells has shown promise; however, there are no readily available HLA-matched anti-viral T cells to facilitate rapid treatment.
View Article and Find Full Text PDFObjectives: With a projected rise in care home residency and the disproportionate impact of epilepsy and seizures on older adults, understanding seizure-related needs in this population is crucial. Data silos and inconsistent recording of residence status make this challenging. We thus leveraged ambulance data to investigate seizure call-out incidence, characteristics, management and costs in care homes compared with the wider community.
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