[Is it possible to predict individual stress resistance by evaluating low dose benzodiazepine effect in modeled emotional stress].

Individual effects of the benzodiazepine tranquilizers phenazepam and gidazepam were studied in neurotic patients and in healthy volunteers tested for the operatory performance under emotiogenic conditions. It was found that manifestations of the tranquiliactivating, tranquilizing, and tranquilisedative effects depend on the individual sensitivity types of the patients and volunteers. The activating manifestations were most pronounced in hypostenic patients, while the sedative action was most significant in hyperstenic persons.

[Predicting individual reactions to emotional stress and benzodiazepine tranquilizers].

The results of pharmacogenetic experiments revealed specificity of the emotional-stress reactions (ESR) in the inherited deterministic type of behavior and showed dependence of the benzodiazepine tranquilizer action on the ESR phenotype. Based on these data, we carried out experiments with a group of volunteers performing operator functions in a model of emotional-stress conditions. The results of these experiments allowed the operators to be divided into stress-resistant and stress-affected groups.

[The mechanisms of the thermal protective action of atsefen].

The study of thermoprotective properties of acephen (300 mg, single dosage) showed an increase (compared to that of placebo) in the maximum endurable time under thermal loading in healthy volunteers: optimization of evaporative heat exchange regime; reduction of the final values of reactive anxiety and fatigue and decrease in the rate of skin temperature growth. In combination with the data of biochemical analysis of peripheral blood which demonstrated positive changes in hormone, lipid, protein, and energy metabolism as well as in vegetative regulation, the results testify to a substantial thermoprotective potential of acephen attributed to the wide range of its pharmacological activity.

[Study of heat-protective effects of bromantane at various levels of overheating].

The thermoprotective properties of bromantane were studied during overheating. Simultaneously with the known effects on heat exchange and sensitivity to high temperatures bromantane caused a decrease in ranges of heat tolerance, increased the rate of SVTK growth as well as altered protein metabolism and antioxidant protection and also affected the autonomic regulation of heat exchange which were essential in adaptation. At the same time, during ergothermal loading accompanied by any troubles in evaporation and heat exchange, marked thermoprotective efficiency of bromantane was compared for its ability to improve muscle dynamometry and hemodynamics as compared with control values.