Exploring the hydrate landscape using data mining on the Cambridge structural database (CSD).

With the continued relevance of drug hydrates in pharmaceutical sciences, a comprehensive understanding of hydrate and anhydrate forms is essential, not only through individual case studies but also from a broader, systematic perspective. The Cambridge Structural Database (CSD) is a well-established database for crystal structures of organic molecules and here, the structural features of pharmaceutically relevant compounds forming hydrates were explored. Drug anhydrate and hydrate subsets were generated and further classified into separate anhydrate and hydrate sets for free drug, cocrystal/solvate, salt, multicomponent cocrystal/solvate, and salt cocrystal/solvate systems.

An observational post-authorization study to assess the effectiveness of a single dose Ad26.COV2.S for the prevention of COVID-19 using real-world data.

Background: The goal of this FDA-committed, post authorization study was to assess the real-world effectiveness of Ad26.COV2.S in preventing observed COVID-19 disease in individuals in the United States interacting with the healthcare system who were vaccinated according to the national immunization recommendations.

Occupational health of drilling waste workers as related to microbial exposure and waste treatment methods.

Objectives: Exposure to microorganisms is a known contributor to occupational disease. This study assessed drilling waste workers' health status and investigated the potential of inhalable bioaerosols to elicit an immune response in vitro and in vivo.

Methods: Venous blood and self-reported health data were collected from 56 and 73 Norwegian drilling waste workers, respectively.

Indoor air quality and symptoms of acute respiratory infections and gastrointestinal issues in children and employees in day-care nurseries.

Background: Children attending day-care centers (DCCs) experience more infections than those cared for at home and DCC employees have high sickness absence rates. This study aimed to investigate the association between indoor air quality (IAQ) and absenteeism among children and staff in DCCs.

Methods: CO levels, relative humidity (RH), and temperature were continuously measured in 22 DCCs over three winter months.