Resilient tree-planting strategies for carbon dioxide removal under compounding climate and economic uncertainties.

To meet decarbonization targets, nations around the globe have made ambitious commitments to expand forested land. Operationalizing these commitments requires choosing a planting strategy: How many trees should be planted, of which species, and where? Given those choices must be made now but have long-term consequences, such decisions are plagued by uncertainty. For example, species that are well suited to present conditions may perform poorly under future climates, yet those future climates are themselves highly uncertain.

Serious Neurologic Adverse Events in Tofersen Clinical Trials for Amyotrophic Lateral Sclerosis.

Introduction/aims: Tofersen is approved for the treatment of amyotrophic lateral sclerosis (ALS) due to superoxide dismutase 1 mutations (SOD1-ALS). Here we report serious neurologic adverse events (AEs) that occurred in the tofersen clinical trials in people with SOD1-ALS.

Methods: Serious neurologic AEs of myelitis, radiculitis, aseptic meningitis, and papilledema reported in the tofersen clinical trials are described.

Can All Behavioral Problems Be Blamed on Equine Gastric Ulcer Syndrome?

Behavioral problems are a common complaint in equine practice, particularly in sport horses [...

How to make land use policy decisions: Integrating science and economics to deliver connected climate, biodiversity, and food objectives.

Land use change is crucial to addressing the existential threats of climate change and biodiversity loss while enhancing food security [M. Zurek , , 1416-1421 (2022)]. The interconnected and spatially varying nature of the impacts of land use change means that these challenges must be addressed simultaneously [H.