EchoAGE: Echocardiography-based Neural Network Model Forecasting Heart Biological Age.

Biological age is a personalized measure of the health status of an organism, organ, or system, as opposed to simply accounting for chronological age. To date, there have been known attempts to create estimators of biological age based on various biomedical data. In this work, we focused on developing an approach for assessing heart biological age using echocardiographic data.

[Wiedemann-Rautenstrauch syndrome. The first description of a clinical case in the Russian Federation].

Wiedemann-Rautenstrauch syndrome (neonatal progeroid syndrome) is an ultra-orphan disease from the group of premature aging syndromes with an autosomal recessive type of inheritance associated with mutations in the POLR3A, POLR3B, and POLR3GL genes encoding RNA polymerase III. The incidence of the disease is currently unknown. We present the first clinical description in Russian Federation of a patient 7 years 6 months old with Wiedemann-Rautenstrauch syndrome (compound heterozygous mutations in POLR3A gene) with progeroid features, adentia, growth retardation (height SDS -3,41, height velocity SDS -2,47), underweight (BMI SDS -6,20), and generalized lipodystrophy.