Effect of Sodium Nitrite and L-NNA on the Outcome of Experimental Ischemic Stroke.

We studied the effect of sodium nitrite in doses of 5 and 50 mg/kg and NO synthase inhibitor L-NNA in a dose of 20 mg/kg on the course of experimental ischemic stroke caused by occlusion of both carotid arteries. Sodium nitrite and NO synthase inhibitor were administered 1 h prior to occlusion of еру carotid arteries and 5 sec after brain ischemia. Sodium nitrite in a dose of 5 mg/kg had a protective effect on the time course of neurological disorders and reduced animal mortality.

[Inhibitors of neuronal and inducible NO-syntases enhance the effect of short-term adaptation to hypoxia in rats of Krushinsky-Molodkina strain].

We found that selective inhibitors of neuronal and inducible NOS (7-nitroindazole and aminoguanidine) significantly enhance the protective effect of short-term adaptation to hypoxia on the development of stress lesions in rats Krushinsky-Molodkina.

[The influence of inhibitors of neuronal and inducible NO-synthases on experimental hemorrhagic stroke].

Objectives. To study the effect of inhibitors of neuronal and inducible NO-synthase on the development of hemorrhagic stroke in rats Krushinsky-Molodkina (KM) without adaptation to hypoxia and with short-term adaptation to hypobaric hypoxia. Material and methods.

Protective effect of magnesium nitrate against neurological disorders provoked by cerebral ischemia in rats.

The study examined effects of inorganic magnesium agents: magnesium nitrate Mg(NO3)2, magnesium sulfate MgSO4, and magnesium chloride MgCl2 on the development of neurological disorders and mortality in rats resulting from cerebral ischemia provoked by a single-stage bilateral occlusion of the common carotid arteries. The rats were injected with one of examined magnesium preparations (5 mg/1 kg body weight) 1 h prior to or 1-2 sec after occlusion. The control group rats were treated with physiological saline at the same terms.

[The effect of magnesium nitrate on the outcome of experimental acute ischemic stroke].

Objectives. To explore the effect of inorganic forms of magnesium (magnesium nitrate, magnesium sulfate, magnesium chloride) on the course of experimental ischemic stroke (II). Material and methods.