Publications by authors named "A L Krarup"
Introduction: Among all Danish dying patients, 80% rely on non-specialised palliative care, an area lacking national and international guidelines. In this pilot study, we developed and tested an acute basic palliation concept (ABPC), a structured end-of-life (EOL) care plan for patients discharged from the emergency department to die at home compared with standard care.
Methods: This study compared symptom scores and EOL care statement scores during a standard care period with an ABPC period using unvalidated questionnaires.
Sex-related differences in the presentation, management and response to treatment of eosinophilic esophagitis: Cross sectional analysis of EoE CONNECT registry.
United European Gastroenterol J
December 2024
Background: Eosinophilic esophagitis (EoE) predominantly affects males across all ages; however, little is known about sex differences for other aspects of EoE.
Objective: To investigate associations between sex and clinical presentation, endoscopic features, treatment choice and response in EoE patients in real-world practice.
Methods: Cross-sectional analysis of the multicenter EoE CONNECT registry.
Article Synopsis
- - The study analyzed treatment differences for eosinophilic esophagitis (EoE) between patients at specialized centers (EoE-Cph cohort) and a broader population (DanEoE cohort), focusing on pre-treatment practices, follow-up, and remission rates during budesonide treatment.
- - Results showed that while a higher percentage of DanEoE patients were on proton pump inhibitors before starting treatment, follow-up rates post-treatment were also more consistent in this group; however, histologic follow-up rates after treatment were similar between both cohorts.
- - The authors concluded that there wasn't enough evidence to recommend treating EoE exclusively at specialized centers, pointing out issues with conflicting responses to treatment and the impact
Background: Eosinophilic oesophagitis (EoE) is a chronic immune-mediated disease. In Denmark, the budesonide orodispersible tablet (BOT) is recommended as a second-line treatment for proton pump inhibitor-refractory EoE patients.
Aims: To evaluate the effectiveness of treatment with BOT in adult EoE patients in a population-based setting in Denmark.
Background & Aims: Clostridioides difficile infection (CDI) is associated with high mortality. Fecal microbiota transplantation (FMT) is an established treatment for recurrent CDI, but its use for first or second CDI remains experimental. We aimed to investigate the effectiveness of FMT for first or second CDI in a real-world clinical setting.
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