Identification of novel KRAS neoantigen specific TCRs and a strategy to eliminate off-target recognition.

Background: T cell receptor (TCR)-engineered T cells targeting neoantigens originated from mutations in KRAS gene have demonstrated promising outcomes in clinical trials against solid tumors. However, the challenge lies in developing tumor-specific TCRs that avoid cross-reactivity with self-antigens to minimize the possibility of severe clinical toxicities. Current research efforts have been put towards strategies to eliminate TCR off-target recognition.

Descriptions of four species of Polyxenida Verhoeff, 1934 (Diplopoda, Penicillata) from China, including one new species and one new record.

This study describes a new species of Polyxenida from China, , along with a species newly recorded from China: (Miyosi, 1947), and provides additional descriptions of Ishii & Liang, 1990 and Ishii & Liang, 1990. The study conducted mitochondrial cytochrome oxidase subunit I (COI) sequencing for all four species and constructed a phylogenetic tree based on the molecular data. The comprehensive morphological descriptions and molecular analyses confirm the addition of one new species and one newly recorded species for the Polyxenida fauna of China, elevating the total number of known Polyxenida species in the country from 10 to 12.

Toroidal dipole resonances enhanced second-harmonic generation with shallow etching of lithium niobate metasurface.

Lithium niobate (LiNbO) has shown great potential for applications in nonlinear metasurfaces, thanks to its large second-order nonlinear coefficients and high integration capabilities. Optical resonances play a crucial role in further enhancing the nonlinear optical responses of LiNbO metasurfaces (LNMS). In this study, both numerically and experimentally, we designed and fabricated a metasurface structure that supports toroidal dipole (TD) resonance to enhance second-harmonic generation (SHG).

Characterization and Biomedical Applications of Electrospun PHBV Scaffolds Derived from Organic Residues.

This study explores the characterization and application of poly(3-hydroxybutyrate--3-hydroxyvalerate) (PHBV) synthesized from organic residues, specifically milk and molasses. Six PHBV samples with varying 3-hydroxyvalerate (3HV) content (7%, 15%, and 32%) were analyzed to assess how 3HV composition influences their properties. Comprehensive characterization techniques, including NMR, FTIR, XRD, DSC, TGA, and tensile-stress test, were used to evaluate the molecular structure, thermal properties, crystalline structure, and mechanical behavior.

A risk-based approach can guide safe cell line development and cell banking for scaled-up cultivated meat production.

For commercial viability, cultivated meats require scientifically informed approaches to identify and manage hazards and risks. Here we discuss food safety in the rapidly developing field of cultivated meat as it shifts from lab-based to commercial scales. We focus on what science-informed risk mitigation processes can be implemented from neighbouring fields.