The Effect of Window Size on Pathologists' Search for Rare Elements in a Digital Pathology Setting.

Context.—: Digital pathology requires pathologists to assess tissue digitally rather than on an analog microscope, which has been the mainstay tool for tissue assessment for more than a century. The impact of different digital interaction configurations on pathologists' performance is not well understood.

Clinical usefulness of patient-reported-outcome-measurement information system in Pediatric Crohn's Disease: a cross-sectional study.

Objectives: This study evaluated the clinical utility of the Patient-Reported Outcomes Measurement Information System (PROMIS) by comparing it with objective clinical data and validated health-related quality of life (HRQOL) measures in pediatric Crohn's disease (CD) patients.

Study Design: Cross-sectional study. Pediatric CD patients (aged 8-17 years) were enrolled prospectively over eight months from an outpatient pediatric gastroenterology center.

Enzymatic epimerization of monoterpene indole alkaloids in Kratom.

Monoterpene indole alkaloids (MIAs) are a large, structurally diverse class of bioactive natural products. These compounds are biosynthetically derived from a stereoselective Pictet-Spengler condensation that generates a tetrahydro-β-carboline scaffold characterized by a 3 stereocenter. However, a subset of MIAs contain a non-canonical 3 stereocenter.

Buffalo milk quality: a study of seasonal influence on composition and somatic cell count.

Despite buffalo milk being an important food worldwide, not much is known about factors that influence its quality on Brazilian buffalo milk farms. It ranks second in total volume of milk production, with cow milk in first place, but a lack of minimum legal parameters for buffalo milk is another problem faced by some countries, as it happens in Brazil where buffalo population represents less than one percent of dairy cows, even though Brazilian buffalo herd is one of the largest in Latin America, with a successful dairy processing chain. This study investigated the composition and somatic cell counts (SCC) of buffalo milk produced in a high-altitude tropical region in the State of Minas Gerais, Brazil, where buffalo calving naturally happens from February to May.

The role of the radiologist in the dengue endemic: a pictorial essay.

The dengue virus, a member of the family Flaviviridae, is transmitted by mosquitoes and causes a viral disease known as dengue fever that is prevalent in tropical and subtropical regions. It is estimated that there are 100-400 million new infections every year, with underreporting due to limited surveillance systems. The presentation ranges from asymptomatic to dengue shock syndrome.