Publications by authors named "A L Hurwitz"

The pathophysiology of osteoarthritis (OA) involves the destruction of articular cartilage and the overgrowth of bone with lipping and spur formation. Nerve endings in the joint capsule and adjacent tissues play a major role in the pain mechanisms of osteoarthritis. This often requires patients to seek pain control measures beyond over-the-counter drugs, such as local anesthetics.

View Article and Find Full Text PDF
Article Synopsis
  • Altered protein phosphorylation in cancer cells can create neoantigens, but their role in cancer immunity is not well understood.
  • This study explores how a specific phosphoneoantigen, pMLL, is recognized by a T cell receptor (TCR27), which may be useful for cancer immunotherapy.
  • Findings indicate that substituting phosphoserine affects TCR27’s ability to activate T cells, underscoring the importance of phosphate interactions for TCR specificity and potential new treatment strategies.
View Article and Find Full Text PDF

Studies conducted during the COVID-19 Pandemic have reported increased rates of mental illnesses including depression, anxiety, and post-traumatic stress disorder (PTSD) [1]. A common symptom of mental illness is change in Rapid Eye Movement (REM) sleep, the phase of sleep associated with dreaming and nightmares. The COVID-19 pandemic offers a unique opportunity to evaluate the effects of systemic stress on nightmares.

View Article and Find Full Text PDF

Purpose: Up to 1 million lesbian, gay, bisexual, and transgender (i.e., sexual and gender minority, SGM) individuals in the United States have histories of cancer.

View Article and Find Full Text PDF