Chronic viral mimicry induction following p53 loss promotes immune evasion.

Epigenetic therapies facilitate transcription of immunogenic repetitive elements that cull cancer cells through 'viral mimicry' responses. Paradoxically, cancer-initiating events also facilitate transcription of repetitive elements. Contributions of repetitive element transcription towards cancer initiation, and the mechanisms by which cancer cells evade lethal viral mimicry responses during tumor initiation remain poorly understood.

Entirely Exophytic HPV-associated Endocervical Adenocarcinoma: A Rare But Potentially Aggressive Neoplastic Phenomenon.

A subset of human papillomavirus (HPV)-associated endocervical adenocarcinoma (EA) displays exclusively exophytic growth, with or without a classic villoglandular appearance. Given that increased depth and extent of destructive stromal invasion are associated with poorer prognosis for HPV-associated EA, it is believed that exclusively exophytic tumors are associated with a relatively indolent clinical course. There is, however, a paucity of data regarding the behavior of these neoplasms.

Novel frequency selective Bfocusing passive lenz resonators for substantial MRI signal-to-noise ratio amplification.

The need for increased sensitivity in magnetic resonance imaging (MRI) is crucial for its advancement as an imaging modality. The development of passive Lenz Resonators (LRs) for effective RF magnetic field (B) focusing will improve MRI sensitivity via local amplification of MRI signal, thereby leading to more efficient diagnosis and patient treatment.While there are methods for amplifying the signal from specific nuclei in MRI, such as hyperpolarization, a general solution will be more advantageous and would work in combination with these preexisting methods.

Presence and extent of lymphovascular invasion in surgical stage I squamous cell carcinoma of the cervix: a comprehensive, international, multicentre, retrospective clinicopathological study.

The aim of this study was to determine whether the presence and extent of lymphovascular invasion (LVI) is prognostic in surgical stage I cervical squamous cell carcinoma (SCC). All available tumour slides and/or paraffin blocks from 426 patients with stage I cervical SCC treated surgically with curative intent were collected from 18 institutions and retrospectively analysed. Presence and extent of LVI (focal <5 spaces, extensive ≥5 spaces) were assessed on scanning magnification in large haematoxylin and eosin slide sets in 366 cases.