Publications by authors named "A L Hirschberg"
Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency (CAH) is a rare genetic condition that results in cortisol deficiency and excess production of adrenal androgens. While the introduction of newborn screening for CAH has reduced morbidity and mortality, management of CAH remains challenging. Lifelong treatment with glucocorticoids is required to replace the endogenous cortisol deficiency and reduce excess adrenal androgens.
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- Kidney diseases are linked to aging and the effects of decreased estrogen due to ovarian senescence, leading to reduced kidney function and increased cardiometabolic risks that can result in chronic kidney disease (CKD).
- CKD can negatively impact ovarian function in women during their reproductive years.
- An individualized menopause management approach for women with CKD includes hormone therapy based on personal preferences and cardiovascular risks, lifestyle modifications, regular monitoring, and tailored guidance for those with additional health issues.
Background: Increased access to and indications for genetic testing will lead to more women undergoing risk-reducing salpingo-oophorectomy (RRSO), with a potential impact on sexual function.
Aim: Our objective was to prospectively investigate (1) sexual function in women with pathogenic variant (PV) in genes, before and 1 year after RRSO, and to compare with a healthy age-matched control group and (2) to study if testosterone levels correlate with sexual functioning after RRSO.
Methods: A prospective observational follow-up study of 43 -PV carriers planned for RRSO and 73 healthy-age matched controls.
Objectives: To assess the efficacy and safety of the non-hormonal, neurokinin 3 receptor antagonist, fezolinetant, to treat moderate-severe vasomotor symptoms associated with menopause in individuals unsuitable for hormone therapy.
Design: Phase 3b randomised controlled trial.
Setting: 16 countries.
Introduction: Fear of cancer recurrence (FCR) is prevalent and distressing among survivors of cancer. Evidence-based mind-body and cognitive-behavioral skills lack integration and testing in scalable formats.
Objective: This pilot randomized controlled trial (NCT04876599) tested a synchronous, virtual mind-body group resiliency intervention for FCR (IN FOCUS).