Publications by authors named "A L Heffernan"

Article Synopsis
  • Ventriculitis in critically ill neurocritical care patients increases the risk of complications and death, prompting a need for improved antibiotic dosing strategies.
  • The study aimed to create a population pharmacokinetic (PK) model for piperacillin-tazobactam (PTZ) by analyzing samples from neurosurgical patients to determine effective dosing for cerebrospinal fluid (CSF) treatment.
  • Results showed significant inter-individual variability in drug penetration into CSF, making it difficult to recommend optimal dosing regimens despite some patients achieving high plasma drug levels.
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It has been thirty years since the end of political apartheid in South Africa in 1994. Those decades have been marked by single-party dominance under the African National Congress (ANC), and the expansion of democratic rights and public goods like education, as well as neoliberal economic policies, growing inequality and, in recent years, corruption and maladministration scandals. On the heels of a historic election in May 2024, one which marked the end of the ANC's electoral dominance and was shaped, in part, by government mismanagement of the energy sector and extensive infrastructural decline, it is a timely moment to consider the history of South Africa's state and its relation to industries of extraction and energy production.

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